Detectives released a new “age progression” image of the toddler, which they said showed what she would look like today at the age of nine.
On Wednesday, Britain’s biggest police force said that as a result of evidence uncovered during a review “they now believe there is a possibility Madeleine is still alive”.
Officers have so far identified nearly 200 new items for investigation within historic material and are also “developing what they believe to be genuinely new material”.
Scotland Yard urged Portuguese authorities to reopen the search for her amid the new "investigative opportunities".
Police said the image, created ahead of what would have been her ninth birthday on May 12, had been created in “close collaboration with the family”.